Transaction outside normal hours (e.g. 95% of transactions - for the merchant in question - take place during business hours, but this transaction is taking place at midnight, on a Saturday)
High dollar amount - the highest potential dollar amount for the merchant in question
Email address is hotmail, gmail, yahoo or some other free service, despite the fact that the merchant is doing B2B transactions only
IP address, email, address and phone number do not match (e.g. IP address in Texas, email provider in UK, phone number is bogus - however the credit card might be genuine)
When contacted about the transaction (by phone or email), fraudster does not reply
Purchase is about getting private data (e.g. resume contact information)
Note: each of the above triggers does not mean that the transaction is fraudulent; it is the simultaneous occurrence of all the above triggers that should generate a very strong red flag.